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Article

Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2008

Anderson Ana C, Chandwaskar Rucha, Lee David H, Kuchroo Vijay K

Abstract excerpt

The Idd3 genetic interval confers protection against multiple autoimmune diseases, including type 1 diabetes and experimental autoimmune encephalomyelitis. The favored candidate gene in this interval is Il2, which is polymorphic between susceptible and resistant strains of mice. IL-2 regulates the growth/death of effector T cells as well as the generation/maintenance of regulatory T cells (Tregs), and recent...

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Share to Antigen-Presenting Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Type 1

Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 19017931
DOI: 10.4049/jimmunol.181.11.7449
PMCID: PMC2614216

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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