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Article

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2015

Fuhrman Christopher A, Yeh Wen-I, Seay Howard R, Saikumar Lakshmi Priya, Chopra Gaurav, Zhang Lin, Perry Daniel J, McClymont Stephanie A, Yadav Mahesh, Lopez Maria-Cecilia, Baker Henry V, Zhang Ying, Li Yizheng, Whitley Maryann, von Schack David, Atkinson Mark A, Bluestone Jeffrey A, Brusko Todd M

Abstract excerpt

Regulatory T cells (Tregs) play a central role in counteracting inflammation and autoimmunity. A more complete understanding of cellular heterogeneity and the potential for lineage plasticity in human Treg subsets may identify markers of disease pathogenesis and facilitate the development of optimized cellular therapeutics. To better elucidate human Treg subsets, we conducted direct transcriptional profiling of...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25994968
DOI: 10.4049/jimmunol.1402381
PMCID: PMC4475416

Genes

TIGIT
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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