Article

Selective ablation of thymic and peripheral Foxp3 <sup>+</sup> regulatory T cell development

2023-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Foxp3 + Treg cells of thymic (tTreg) and peripheral (pTreg) developmental origin are thought to synergistically act to ensure immune homeostasis, with self-reactive tTreg cells primarily constraining autoimmune responses. We exploited tTreg-specific GFP/Cre recombinase activity to selectively ablate either tTreg (ΔtTreg) or pTreg (ΔpTreg) cell development. In contrast to the tTreg cell behavior...

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Literature Corpus work: e2fecf57-d5c3-536c-af16-c3ba5c04430b
DOI: 10.1101/2023.08.04.551974

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