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Article

Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2011

Joller Nicole, Hafler Jason P, Brynedal Boel, Kassam Nasim, Spoerl Silvia, Levin Steven D, Sharpe Arlene H, Kuchroo Vijay K

Abstract excerpt

Costimulatory molecules regulate the functional outcome of T cell activation, and disturbance of the balance between activating and inhibitory signals results in increased susceptibility to infection or the induction of autoimmunity. Similar to the well-characterized CD28/CTLA-4 costimulatory pat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21199897
DOI: 10.4049/jimmunol.1003081
PMCID: PMC3128994

Genes

TIGIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21199897-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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