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Article

CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340.

Journal of leukocyte biology - 1 Apr 2020

Mu Yang, Zhang Jinxue, Liu Yongming, Ma Jingchang, Jiang Dongxu, Zhang Xuexin, Yi Xin, Cheng Kun, Shen Shen, Yang Yixin, Zhuang Ran, Zhang Yuan

Abstract excerpt

In this study, we observed that deletion of CD226 on regulatory T cells (Tregs) precedes renal fibrosis in a mouse unilateral ureteral obstruction (UUO) model. First, we generated Treg-specific CD226 gene knockout mice (CD226fl/fl Foxp3YFP-Cre ). Next, CD226fl/fl Foxp3YFP-Cre mice and Foxp3YFP-Cre control mice were subjected to UUO surgery. Pathologic analysis and Sirius red and Masson's trichrome staining showed...

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Identifiers

PMID: 31802539
DOI: 10.1002/JLB.2MA1119-174RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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