Article

The effects of <i>CDC45</i> mutations on DNA replication and genome stability

2024-10-31

Abstract excerpt

Cdc45 is a non-catalytic subunit of the CMG helicase complex and is recruited to the autonomously replicating sequence at the onset of DNA replication. Cdc45 protein is required for the initiation of the DNA replication process as well as for the nascent DNA strand synthesis. It interacts with Mcm2 and Psf1 elements of CMG helicase, as well as with Sld3, and initiation factor, and Pol2, the catalytic subunit of DN...

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Literature Corpus work: fad94c83-a47e-56c2-86e9-63b862f0f82e
DOI: 10.1101/2024.10.28.620574

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