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Article

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Nov 2007

Hoang Margaret L, Leon Ronald P, Pessoa-Brandao Luis, Hunt Sonia, Raghuraman M K, Fangman Walton L, Brewer Bonita J, Sclafani Robert A

Abstract excerpt

Eukaryotic chromosomal replication is a complicated process with many origins firing at different efficiencies and times during S phase. Prereplication complexes are assembled on all origins in G(1) phase, and yet only a subset of complexes is activated during S phase by DDK (for Dbf4-dependent kinase) (Cdc7-Dbf4). The yeast mcm5-bob1 (P83L) mutation bypasses DDK but results in reduced intrinsic firing efficiency...

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Identifiers

PMID: 17724082
DOI: 10.1128/MCB.00997-07
PMCID: PMC2169039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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