Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.

The Journal of biological chemistry - 15 Mar 2013

Bruck Irina, Kaplan Daniel L

Abstract excerpt

Replicative polymerase stalling is coordinated with replicative helicase stalling in eukaryotes, but the mechanism underlying this coordination is not known. Cdc45 activates the Mcm2-7 helicase. We report here that Cdc45 from budding yeast binds tightly to long (≥ 40 nucleotides) genomic single-stranded DNA (ssDNA) and that 60mer ssDNA specifically disrupts the interaction between Cdc45 and Mcm2-7. We identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anisotropy
Share to Biotin
Share to Cell Separation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to DNA Helicases

Share to DNA, Single-Stranded

Share to Hydroxyurea

Share to Saccharomycetales

Source

Open in PubMed Open full text

Identifiers

PMID: 23382391
DOI: 10.1074/jbc.M112.440941
PMCID: PMC3597796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.PMID 23382391Read ↗

Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding.Semantic proximity Read ↗

Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication.Semantic proximity Read ↗

CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication.Semantic proximity Read ↗

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.Semantic proximity Read ↗

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.Semantic proximity Read ↗

Ino80 chromatin remodeling complex promotes recovery of stalled replication forks.Semantic proximity Read ↗

Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Semantic proximity Read ↗

Cdc45 is limiting for replication initiation in humansSemantic proximity Read ↗

Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.Semantic proximity Read ↗

The effects of <i>CDC45</i> mutations on DNA replication and genome stabilitySemantic proximity Read ↗

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p.Semantic proximity Read ↗

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.