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DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in <i>Leishmania donovani</i> and the Cdc45 PIP box is essential for cell survival

2019-11-05

Abstract excerpt

DNA replication protein C dc45 is an integral part of the eukaryotic replicative helicase whose other components are the M cm2-7 core, and G INS. We identified a PIP box motif in Leishmania donovani Cdc45. This motif is typically linked to interaction with the eukaryotic clamp p roliferating c ell n uclear a ntigen (PCNA). The homotrimeric PCNA can potentially bind upto three different proteins simultaneou...

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Literature Corpus work
5e1bb171-8350-53ef-8080-63c54d5cb215
DOI
10.1101/831669
Open publication

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DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in <i>Leishmania donovani</i> and the Cdc45 PIP box is essential for cell survivalDOI 10.1101/831669
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