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Article

High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6

1 Jun 2022

Abstract excerpt

OBJECTIVES: CDC45 is the core component of CMG (CDC45-MCMs-GINS) complex that plays important role in the initial step of DNA replication in eukaryotic cells. The expression level of cdc45 is under the critical control for the accurate cell cycle progression. Loss-of-function of cdc45 has been demonstrated to inhibit cell proliferation and leads to cell death due to the inhibition of DNA replication and G1-phase...

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PMID: 35642733
DOI: 10.1111/cpr.13257

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