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Article

Cdc45 is limiting for replication initiation in humans

26 Feb 2016

Abstract excerpt

Cdc45 is an essential protein that together with Mcm2-7 and GINS forms the eukaryotic replicative helicase CMG. Cdc45 seems to be rate limiting for the initial unwinding or firing of replication origins. In line with this view, Cdc45-overexpressing cells fired at least twice as many origins as control cells. However, these cells displayed an about 2-fold diminished fork elongation rate, a pronounced asymmetry of...

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Identifiers

PMID: 26919204
DOI: 10.1080/15384101.2016.1152424

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