Article

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

2019-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, impacting the accuracy of PDX modeling of human cancer. Here we exhaustively analyze copy number alterations (CNAs) in 1451 PDX and matched patient tumor (PT) sampl...

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Literature Corpus work: fab79c42-324d-5d19-a928-fc31bb926cbf
DOI: 10.1101/861393

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