Article

DNA-based copy number analysis confirms genomic evolution of PDX models

2021-01-17

Abstract excerpt

We previously reported the genomic evolution of the copy number (CN) landscapes of patient-derived xenografts (PDXs) during their engraftment and passaging 1 . Woo et al. argue that the CN profiles of PDXs are highly conserved, and that the main conclusions of our paper are invalid due to our use of expression-based CN profiles 2 . Here, we reassess genomic evolution of PDXs using the DNA-based CN profiles repor...

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Literature Corpus work: a97c357f-7cf4-517a-b011-47e25a9fefb9
DOI: 10.1101/2021.01.15.426865

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