Article
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.
Nature genetics - 1 Jan 2021
Woo Xing Yi, Giordano Jessica, Srivastava Anuj, Zhao Zi-Ming, Lloyd Michael W, de Bruijn Roebi, Suh Yun-Suhk, Patidar Rajesh, Chen Li, Scherer Sandra, Bailey Matthew H, Yang Chieh-Hsiang, Cortes-Sanchez Emilio, Xi Yuanxin, Wang Jing, Wickramasinghe Jayamanna, Kossenkov Andrew V, Rebecca Vito W, Sun Hua, Mashl R Jay, Davies Sherri R, Jeon Ryan, Frech Christian, Randjelovic Jelena, Rosains Jacqueline, Galimi Francesco, Bertotti Andrea, Lafferty Adam, O'Farrell Alice C, Modave Elodie, Lambrechts Diether, Ter Brugge Petra, Serra Violeta, Marangoni Elisabetta, El Botty Rania, Kim Hyunsoo, Kim Jong-Il, Yang Han-Kwang, Lee Charles, Dean Dennis A, Davis-Dusenbery Brandi, Evrard Yvonne A, Doroshow James H, Welm Alana L, Welm Bryan E, Lewis Michael T, Fang Bingliang, Roth Jack A, Meric-Bernstam Funda, Herlyn Meenhard, Davies Michael A, Ding Li, Li Shunqiang, Govindan Ramaswamy, Isella Claudio, Moscow Jeffrey A, Trusolino Livio, Byrne Annette T, Jonkers Jos, Bult Carol J, Medico Enzo, Chuang Jeffrey H
Abstract excerpt
Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting the accuracy of PDX modeling of human cancer. Here, we exhaustively analyze copy number alterations (CNAs) in 1,451 PDX and matched patient tumor (PT) samples from 509 PDX...
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