Article

In Search of the Perfect Model: How Cancer Cell Lines Relate to Native Cancers

2024-06-11

Abstract excerpt

<title>Abstract</title> <p>Cancer cell lines are frequently used in biological and translational research to study cellular mechanisms and explore treatment options. However, cancer cell lines may display mutational profiles divergent from native cancers or may be misidentified or contaminated. We explored how similar cancer cell lines are to native cancers to find the most suitable representations for the corres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47124148-a909-5bf5-8c33-40c3b0032672
DOI: 10.21203/rs.3.rs-4424943/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In Search of the Perfect Model: How Cancer Cell Lines Relate to Native CancersDOI 10.21203/rs.3.rs-4424943/v1Read

In Search of the Perfect Model: How Cancer Cell Lines Relate to Native CancersSemantic proximity Read

Evaluating cell lines as tumour models by comparison of genomic profiles.Semantic proximity Read

Optimization of cell lines as tumour models by integrating multi-omics data.Semantic proximity Read

Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancerSemantic proximity Read

Comparing cancer cell lines and tumor samples by genomic profilesSemantic proximity Read

CNpare: matching DNA copy number profilesSemantic proximity Read

Connecting Cancers to Chromosomal Locations Through Copy Number VariationsSemantic proximity Read

Matching cancer genomes to established cell lines for personalized oncology.Semantic proximity Read

Genomic profiling of cell lines reveals hidden research bias and caveatsSemantic proximity Read

Identification of malignant cells in single-cell transcriptomics dataSemantic proximity Read

cancercelllines.org-a novel resource for genomic variants in cancer cell lines.Semantic proximity Read

Inferring copy number variation from gene expression data: methods, comparisons, and applications to oncologySemantic proximity Read