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Article

Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations

28 Jun 2011

Abstract excerpt

BACKGROUND: Human tumors transplanted into immunodeficient mice (xenografts) are good preclinical models, and it is important to identify possible systematic changes during establishment and passaging in mice. METHODS: High-resolution microarray-based comparative genomic hybridization (array CGH) was used to investigate how well a series of sarcoma xenografts, including 9 patient/xenograft pairs and 8 early...

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PMID: 21713766
DOI: 10.1002/cncr.26276

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