Article

Genomic evolution of non-small cell lung cancer patient-derived xenograft models

2023-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Patient-derived xenograft (PDX) models of cancer, developed through injection of patient tumour cells into immunocompromised mice, have been widely adopted in preclinical studies, as well as in precision oncology approaches. However, the extent to which PDX models represent the underlying genetic diversity of a patient’s tumour and the extent of on-going genomic evolution in PDX models are incom...

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Literature Corpus work: 3c247020-6141-5df4-8f04-060ebb11999f
DOI: 10.1101/2023.01.06.521078

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