Article

Patient-derived xenografts undergo murine-specific tumor evolution

2017-07-24

Abstract excerpt

Patient-derived xenografts (PDXs) have become a prominent model for studying human cancer in vivo . The underlying assumption is that PDXs faithfully represent the genomic features of primary tumors, retaining their molecular characteristics throughout propagation. However, the genomic stability of PDXs during passaging has not yet been evaluated systematically. Here we monitored the dynamics of copy number alter...

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Literature Corpus work: e1ec9933-b9ff-5d1d-b4e7-4a7ccf1319da
DOI: 10.1101/167767

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