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Article

Genomic fidelity and evolution of cancer patient-derived organoids

2025-12-11

Abstract excerpt

<h4>Background</h4> Patient-derived organoids (PDOs) are gaining recognition as a promising ex vivo model for cancer research, offering advantages over traditional 2D cell lines by better recapitulating tumor biology. <h4>Results</h4> In this study, we assess the genomic stability and evolution of PDOs by analyzing copy-number alterations (CNAs) in 300 PDO samples across 16 cancer types. These results are comp...

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Literature Corpus work
a9e4c915-3763-587f-a205-49be0c3c57c0
DOI
10.64898/2025.12.10.693393
Open publication

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Genomic fidelity and evolution of cancer patient-derived organoidsDOI 10.64898/2025.12.10.693393
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