Article

Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice

2025-12-04

Abstract excerpt

<title>Abstract</title> Alzheimer’s disease (AD) is frequently accompanied by neuropsychiatric symptoms (NPS), among which apathy, one of the most prevalent and burdensome, accelerates cognitive decline and disease progression, yet its molecular underpinnings remain unclear. Our previous RNA-sequencing of AD subjects revealed abnormal immune gene expression uniquely associated with apathy. In this study, we...

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Literature Corpus work: fa24b487-1c6b-5431-92c1-33de2c959c9f
DOI: 10.21203/rs.3.rs-8031077/v1

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Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD miceDOI 10.21203/rs.3.rs-8031077/v1Read

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