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Complement therapeutics in neurodegenerative diseases

16 Jun 2025

Abstract excerpt

Neurodegenerative diseases (NDDs) such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis pose considerable therapeutic challenges, not only due to their complex pathophysiology, but also because any effective drug must be capable of penetrating the brain. Inflammation is a key feature of NDDs. Increasingly, the complement system, long studied in the context of host defence, has emerged as a central...

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PMID: 40544661
DOI: 10.1016/j.imbio.2025.153089

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