Article

Neurotrophic Factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer’s Disease mice

2025-06-08

Abstract excerpt

<h4>Background</h4> The global aging population is increasingly inflicted with Alzheimer’s disease (AD), but a cure is still unavailable. Neurotrophic Factor-α1/carboxypeptidase E (NF-α1/CPE) gene therapy has been shown to prevent and reverse memory loss and pathology AD mouse models However, the mechanisms of action of NF-α1/CPE are not fully understood. We investigated if a non-enzymatic form of NF-α1/CPE-E342Q...

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Literature Corpus work: 1e76b213-350e-509c-8a60-1207379e6ed0
DOI: 10.1101/2025.06.04.657876

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