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Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy

2024-10-29

Abstract excerpt

Alzheimer’s disease (AD) and epilepsy (EP) share a complex bidirectional relationship, yet the molecular mechanisms underlying their comorbidity remain insufficiently explored. To identify potential transcriptional programs across animal models and human patients with AD and EP, we conducted a comprehensive genome-wide transcriptomic analysis. Our investigation included mouse models of temporal lobe epilepsy (pilo...

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Literature Corpus work
c88711b0-bfc4-5a15-8719-a145da900a89
DOI
10.1101/2024.10.28.618752
Open publication

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Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsyDOI 10.1101/2024.10.28.618752
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