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<i>Apolipoprotein E ε4</i> exacerbates microglia-mediated complement-dependent synapse loss caused by neuronal <i>Tpk</i> deficiency

2025-01-17

Abstract excerpt

Thiamine pyrophosphokinse-1 (TPK) is a key enzyme that converts thiamine to functional thiamine diphosphate (TDP). TPK insufficiency and hence TDP reduction in neurons induced by amyloid-β deposition and diabetes, an independent risk factor of Alzheimer’s disease (AD), recapitulate multi-pathophysiological features in the brain of mice, similar to those in human AD. Apolipoprotein E ε 4 allele ( APOE4 ) is the...

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Literature Corpus work
f3882e53-6217-566c-b026-31563febd596
DOI
10.1101/2025.01.16.633468
Open publication

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