Article

De novo design of epitope-specific antibodies against soluble and multipass membrane proteins with high specificity, developability, and function

2025-01-22

Abstract excerpt

We present JAM, a generative protein design system that enables fully computational design of antibodies with therapeutic-grade properties for the first time. JAM generates antibodies de novo in both single-domain (VHH) and paired (scFv/mAb) antibody formats that achieve double-digit nanomolar affinities, strong early-stage developability profiles, and precise epitope targeting without experimental optimization. W...

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Literature Corpus work: f9c9820e-7d46-5f28-917a-b28d413885f0
DOI: 10.1101/2025.01.21.633066

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