Article

<i>De novo</i> design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time compute

2025-05-30

Abstract excerpt

We present significant advances in de novo antibody design against G protein-coupled receptors (GPCRs) enabled by scaling the test-time compute used by our generative protein design system, JAM. We de novo design hundreds of VHH (single domain) antibodies against CXCR4 and CXCR7, with top designs showing picomolar to low-nanomolar affinities, high selectivity, and favorable early-stage developability profiles, m...

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Literature Corpus work: fcc6106a-787f-594f-a709-0fe52e15bbf5
DOI: 10.1101/2025.05.28.656709

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