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De novo design of therapeutic scFvs and multi-specific engagers from sequence alone

2026-03-18

Abstract excerpt

The discovery of functional antibody therapeutics is fundamentally constrained by the astronomical complexity of the sequence landscape and the inefficiency of empirical screening. While structure-based computational design has made significant strides, its reliance on high-resolution co-complex data restricts its utility against the vast undruggable proteome and rapidly evolving pathogens. Here, we introduce IASO...

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Literature Corpus work
44c340ad-2575-5b58-a53a-a6d3a639b639
DOI
10.64898/2026.03.17.712263
Open publication

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De novo design of therapeutic scFvs and multi-specific engagers from sequence aloneDOI 10.64898/2026.03.17.712263
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