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OptMAVEn-2.0: De novo Design of Variable Antibody Regions against Targeted Antigen Epitopes

30 Jun 2018

Abstract excerpt

Monoclonal antibodies are becoming increasingly important therapeutic agents for the treatment of cancers, infectious diseases, and autoimmune disorders. However, laboratory-based methods of developing therapeutic monoclonal antibodies (e.g., immunized mice, hybridomas, and phage display) are time-consuming and are often unable to target a specific antigen epitope or reach (sub)nanomolar levels of affinity. To...

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PMID: 31544875
DOI: 10.3390/antib7030023

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