A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies

Abstract excerpt

Single-domain antibodies (sdAbs) have emerged as powerful therapeutic agents due to their small size, high stability, and superior tissue penetration. However, unlike conventional monoclonal antibodies (mAbs), sdAbs lack an Fc domain, limiting their functional versatility and manufacturability. To address this challenge, we developed TFDesign-sdAb, a deep learning-based generative-ranking framework that enables ra...

Topics

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• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

dac1b4d9-d5db-5027-8698-b94a7371d2bd

DOI

10.1101/2025.05.09.653014