Article

A high-throughput platform for biophysical antibody developability assessment to enable AI/ML model training

2025-05-02

Abstract excerpt

Antibodies must bind their targets with high affinity and specificity to achieve useful therapeutic activity. They must also possess suitable developability properties (e.g., thermostability, solubility, viscosity, polyreactivity) to ensure favorable manufacturing, formulation, and in vivo performance. Both binding and developability properties are inherent to a given antibody amino acid sequence. Identification...

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Literature Corpus work: 99c30e68-5296-54a1-ae62-7993e8d8d9b7
DOI: 10.1101/2025.05.01.651684

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