Article

High-throughput ML-guided design of diverse single-domain antibodies against SARS-CoV-2

2023-12-01

Abstract excerpt

Treating rapidly evolving pathogenic diseases such as COVID-19 requires a therapeutic approach that accommodates the emergence of viral variants over time. Our machine learning (ML)-guided sequence design platform combines high-throughput experiments with ML to generate highly diverse single-domain antibodies (VHHs) that bind and neutralize SARS-CoV-1 and SARS-CoV-2. Crucially, the model, trained using binding dat...

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Literature Corpus work: 64d79acc-c83c-5e4f-86cc-cd4f7b6734cf
DOI: 10.1101/2023.12.01.569227

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