Article

Zero-Shot Design of a Biobetter Cetuximab: Enhanced EGFR Affinity with Preserved Developability

2026-05-08

Abstract excerpt

Cetuximab is a chimeric IgG1 monoclonal antibody that has been a cornerstone therapy for EGFR-driven malignancies for nearly two decades. Its therapeutic activity is governed by competitive displacement of endogenous EGFR ligands, making binding affinity a direct determinant of clinical efficacy. We applied ConvergeAB™, a target-aware antibody design platform, in a fully zero-shot configuration to generate a biobe...

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Literature Corpus work: ab7501de-d91e-53ae-b5b8-3f10c52b291a
DOI: 10.64898/2026.05.05.722890

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