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An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics

1 Jan 2021

Abstract excerpt

Next-generation multi-specific antibody therapeutics (MSATs) are engineered to combine several functional activities into one molecule to provide higher efficacy compared to conventional, mono-specific antibody therapeutics. However, highly engineered MSATs frequently display poor yields and less favorable drug-like properties (DLPs), which can adversely affect their development. Systematic screening of a large...

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PMID: 34382900
DOI: 10.1080/19420862.2021.1955433

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