Article
Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.
mAbs - 1 Dec 2025
Dreyer Frédéric A, Schneider Constantin, Kovaltsuk Aleksandr, Cutting Daniel, Byrne Matthew J, Nissley Daniel A, Kenlay Henry, Marks Claire, Errington David, Gildea Richard J, Damerell David, Tizei Pedro, Bunjobpol Wilawan, Darby John F, Drulyte Ieva, Hurdiss Daniel L, Surade Sachin, Wahome Newton, Pires Douglas E V, Deane Charlotte M
Abstract excerpt
Developing therapeutic antibodies is a challenging endeavor, often requiring large-scale screening to produce initial binders, that still often require optimization for developability. We present a computational pipeline for the discovery and design of therapeutic antibody candidates, which incorporates physics- and AI-based methods for the generation, assessment, and validation of candidate antibodies with...
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