Article

<i>In silico</i> design of stable single-domain antibodies with high affinity

2024-04-26

Abstract excerpt

Antibody-based therapeutics have become indispensable in modern medicine, but traditional methods of antibody discovery often present with limitations in developability, cross-reactivity, and ethical concerns. While deep learning and generative approaches have shown promise in the design of high affinity protein binders, de novo antibody design remains challenging. Here, we present EvolveX, a structure-based comp...

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Literature Corpus work: 3aad4e08-4a55-54ad-8598-a379e22805e7
DOI: 10.1101/2024.04.22.589762

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