Article

Atomically accurate de novo design of antibodies with RFdiffusion

2024-03-18

Abstract excerpt

Despite the central role that antibodies play in modern medicine, there is currently no method to design novel antibodies that bind a specific epitope entirely in silico . Instead, antibody discovery currently relies on animal immunization or random library screening approaches. Here, we demonstrate that combining computational protein design using a fine-tuned RFdiffusion network alongside yeast display screenin...

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Identifiers and source

Literature Corpus work: 7a804da0-2994-58b8-84d6-afb28025c527
DOI: 10.1101/2024.03.14.585103

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