Article

TAD Cliques Predict Key Features of Chromatin Organization

2020-11-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Processes underlying genome 3D organization and domain formation in the mammalian nucleus are not completely understood. Multiple processes such as transcriptional compartmentalization, DNA loop extrusion and interactions with the nuclear lamina dynamically act on chromatin at multiple levels. Here, we explore long-range interaction patterns between topologicall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2412b992-7120-55a1-8526-76dae4ae44f6
DOI: 10.21203/rs.3.rs-112820/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TAD Cliques Predict Key Features of Chromatin OrganizationDOI 10.21203/rs.3.rs-112820/v1Read

TAD cliques predict key features of chromatin organizationSemantic proximity Read

Regulatory roles of three-dimensional structures of chromatin domainsSemantic proximity Read

Evolutionary stability of topologically associating domains is associated with conserved gene regulationSemantic proximity Read

Stratification of TAD boundaries identified in reproducible Hi-C contact matrices reveals preferential insulation of super-enhancers by strong boundariesSemantic proximity Read

DeDoc2 identifies and characterizes the hierarchy and dynamics of chromatin TAD-like domains in the single cellsSemantic proximity Read

DeDoc2 identifies and characterizes the hierarchy and dynamics of chromatin TAD-like domains in the single cellsSemantic proximity Read

Topologically associating domain (TAD) boundaries stable across diverse cell types are evolutionarily constrained and enriched for heritabilitySemantic proximity Read

Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization in human cellsSemantic proximity Read

A comprehensive catalog of 3D genome organization in diverse human genomes facilitates understanding of the impact of structural variation on chromatin structureSemantic proximity Read

Gene structure heterogeneity drives transcription noise within human chromosomesSemantic proximity Read

Spatial Genome Organization as a Framework for Somatic Alterations in Human CancerSemantic proximity Read

Breaking TADs: How Alterations of Chromatin Domains Result in Disease.Semantic proximity Read