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Article

Loop competition and extrusion model predicts CTCF interaction specificity.

Nature communications - 16 Feb 2021

Xi Wang, Beer Michael A

Abstract excerpt

Three-dimensional chromatin looping interactions play an important role in constraining enhancer-promoter interactions and mediating transcriptional gene regulation. CTCF is thought to play a critical role in the formation of these loops, but the specificity of which CTCF binding events form loops and which do not is difficult to predict. Loops often have convergent CTCF binding site motif orientation, but this...

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Share to Carrier Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Identifiers

PMID: 33594051
DOI: 10.1038/s41467-021-21368-0
PMCID: PMC7886907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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