Article

Chromatin accessibility classification of TAD boundaries discloses new architectural proteins

2024-12-20

Abstract excerpt

3D genome organization is crucial to modulate gene expression. Topologically Associated Domains (TADs) isolate genes and their regulatory elements within the same topological neighborhood, avoiding crosstalk between regulatory elements. Perturbation of domain boundaries causes aberrant genomic contacts and gene expression misregulation. Architectural proteins such as CTCF and the cohesin complex are critical to fo...

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Literature Corpus work: 622d1ec0-d746-5257-a8f4-d72dc64a4d34
DOI: 10.1101/2024.12.18.629025

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