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Article

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities.

Nature communications - 14 Dec 2021

Pemovska Tea, Bigenzahn Johannes W, Srndic Ismet, Lercher Alexander, Bergthaler Andreas, César-Razquin Adrián, Kartnig Felix, Kornauth Christoph, Valent Peter, Staber Philipp B, Superti-Furga Giulio

Abstract excerpt

Interrogation of cellular metabolism with high-throughput screening approaches can unravel contextual biology and identify cancer-specific metabolic vulnerabilities. To systematically study the consequences of distinct metabolic perturbations, we assemble a comprehensive metabolic drug library (CeMM Library of Metabolic Drugs; CLIMET) covering 243 compounds. We, next, characterize it phenotypically in a diverse...

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PMID: 34907165
DOI: 10.1038/s41467-021-27329-x
PMCID: PMC8671470

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