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Article

Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq.

Nature communications - 12 Nov 2020

Brockway Sonia, Wang Geng, Jackson Jasen M, Amici David R, Takagishi Seesha R, Clutter Matthew R, Bartom Elizabeth T, Mendillo Marc L

Abstract excerpt

Chemical-genetic interaction profiling in model organisms has proven powerful in providing insights into compound mechanism of action and gene function. However, identifying chemical-genetic interactions in mammalian systems has been limited to low-throughput or computational methods. Here, we develop Quantitative and Multiplexed Analysis of Phenotype by Sequencing (QMAP-Seq), which leverages next-generation...

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Identifiers

PMID: 33184288
DOI: 10.1038/s41467-020-19553-8
PMCID: PMC7661543

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