Article

Architectural fragility of gene regulatory networks underlies hematopoietic stem cell aging

2026-06-04

Abstract excerpt

Hematopoietic stem and progenitor cell (HSPC) aging contributes to immune dysfunction and age-associated disease, but its regulatory mechanisms remain unclear. Here, we present the largest single-cell multiome atlas of human circulating HSPCs to date, with >380,000 paired RNA and ATAC profiles across 77 donors. Beyond recapitulating established hallmarks of HSPC aging, we reconstructed a high-resolution gene regul...

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Literature Corpus work: 36a369ff-2481-5b84-9637-08d86db25bc9
DOI: 10.64898/2026.06.03.729976

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