Article

Improving prediction of core transcription factors for cell reprogramming and transdifferentiation

2022-01-13

Abstract excerpt

Identification of transcription factors (TFs) that could induce and direct cell conversion remains a challenge. Though several hundreds of TFs are usually transcribed in each cell type, the identity of a cell is controlled and can be achieved through the ectopic overexpression of only a small subset of so-called core TFs. Currently, the experimental identification of the core TFs for a broad spectrum of cell types...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 96b1af0a-dee7-5310-9aa1-45284119d465
DOI: 10.12688/f1000research.75321.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Improving prediction of core transcription factors for cell reprogramming and transdifferentiationDOI 10.12688/f1000research.75321.1Read

scDirect: key transcription factor identification for directing cell state transitions based on single-cell multi-omics dataSemantic proximity Read

ANANSE: An enhancer network-based computational approach for predicting key transcription factors in cell fate determinationSemantic proximity Read

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human HematopoiesisSemantic proximity Read

Graph-based tracing of dynamically functioning gene circuits in cell fate decisions with isoform resolutionSemantic proximity Read

An atlas of TF driven gene programs across human cellsSemantic proximity Read

scREMOTE: Using multimodal single cell data to predict regulatory gene relationships and to build a computational cell reprogramming modelSemantic proximity Read

Conserved epigenetic regulatory logic infers genes governing cell identitySemantic proximity Read

Direct conversion of human fibroblasts to pancreatic epithelial cells through transient progenitor states is controlled by temporal activation of defined factorsSemantic proximity Read

Atlas of Regulated Target Genes of Transcription Factors (ART-TF) in Human ES CellsSemantic proximity Read

Super-enhancers in the control of cell identity and disease.Semantic proximity Read

Diversification of Reprogramming Trajectories Revealed by Parallel Single-cell Transcriptome and Chromatin Accessibility SequencingSemantic proximity Read

Transcriptional landscape of direct reprogramming toward the hematopoietic lineageSemantic proximity Read