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Tracking the gene expression programs and clonal relationships that underlie mast, myeloid, and T lineage specification from stem cells

29 Nov 2024

Abstract excerpt

T cells develop from hematopoietic progenitors in the thymus and protect against pathogens and cancer. However, the emergence of human T cell-competent blood progenitors and their subsequent specification to the T lineage have been challenging to capture in real time. Here, we leveraged a pluripotent stem cell differentiation system to understand the transcriptional dynamics and cell fate restriction events that...

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PMID: 39615483
DOI: 10.1016/j.cels.2024.11.001

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