Article

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cells

2021-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Human hematopoiesis is a dynamic process that starts in utero 4 weeks post-conception. Understanding the site- and stage-specific variation in hematopoiesis is important if we are to understand the origin of hematological disorders, many of which occur at specific points in the human lifespan. To unravel how the hematopoietic stem/progenitor cell (HSPC) compartments change during human ontogeny...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2ad31b4-a471-50c8-9719-f765b152644b
DOI: 10.1101/2021.04.20.440420

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cellsDOI 10.1101/2021.04.20.440420Read

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human developmentSemantic proximity Read

Hematopoiesis at single cell resolution spanning human development and maturationSemantic proximity Read

Molecular landscapes of human hematopoietic stem cells in health and leukemiaSemantic proximity Read

Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic HierarchySemantic proximity Read

Decoding human B cell ontogeny in prenatal and adult bone marrow and in vitro models via single-cell multiomicsSemantic proximity Read

Integrative Single-cell RNA-Seq and ATAC-Seq Analysis of Human Developmental HaematopoiesisSemantic proximity Read

The Human Cell Atlas bone marrow single-cell interactive web portalSemantic proximity Read

Robust temporal map of human <i>in vitro</i> myelopoiesis using single-cell genomicsSemantic proximity Read

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activationSemantic proximity Read

Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysisSemantic proximity Read

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolutionSemantic proximity Read

Humanized <i>in vivo</i> bone marrow models orchestrate multi-lineage human hematopoietic cell developmentSemantic proximity Read