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Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development

1 Sept 2021

Abstract excerpt

Human hematopoiesis is a dynamic process that starts in utero 18-21 days post-conception. Understanding the site- and stage-specific variation in hematopoiesis is important if we are to understand the origin of hematological disorders, many of which occur at specific points in the human lifespan. To unravel how the hematopoietic stem/progenitor cell (HSPC) compartment changes during human ontogeny and the...

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PMID: 34525349
DOI: 10.1016/j.celrep.2021.109698

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