Article

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

2020-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Changes in gene regulation and expression govern orderly transitions from hematopoietic stem cells to terminally differentiated blood cell types. These transitions are disrupted during leukemic transformation but knowledge of the gene regulatory changes underpinning this process is elusive. We hypothesised that identifying core gene regulatory networks in healthy hematopoietic and leukemic cells...

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Literature Corpus work: ea8c0baa-679a-5872-95dd-b07778b8d90f
DOI: 10.1101/2020.10.26.353797

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