Article

<i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammals

2022-06-17

Abstract excerpt

Meiotic crossovers are required for accurate chromosome segregation and to produce new allelic combinations. Meiotic crossover numbers are tightly regulated within a narrow range, despite an excess of initiating DNA double-strand breaks. Here, we describe the tumour suppressor FANCM as a meiotic anti-crossover factor in mammals. Crossover analyses with single-gamete and pedigree datasets both reveal a genome-wide...

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Literature Corpus work: f938242c-cb97-59a2-8e70-229d4ed6845c
DOI: 10.1101/2022.06.16.496499

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