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BiallelicHFM1variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degrees

15 Apr 2022

Abstract excerpt

STUDY QUESTION: Do variants in helicase for meiosis 1 (HFM1) account for male infertility in humans? SUMMARY ANSWER: Biallelic variants in HFM1 cause human male infertility owing to non-obstructive azoospermia (NOA) with impaired crossover formation and meiotic metaphase I (MMI) arrest. WHAT IS KNOWN ALREADY: HFM1 encodes an evolutionarily conserved DNA helicase that is essential for crossover formation and...

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DNA Repair Mechanisms
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Sperm and Testicular Function

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35526155
DOI: 10.1093/humrep/deac092

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BiallelicHFM1variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degreesPMID 35526155Read ↗

Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermiaSemantic proximity Read ↗

Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome.Semantic proximity Read ↗

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Novel Variants in HFM1 Lead to Male Infertility Due to Non-obstructive AzoospermiaSemantic proximity Read ↗

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Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermiaSemantic proximity Read ↗

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