Article
The Fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in Arabidopsis.
The Plant cell - 1 Apr 2012
Knoll Alexander, Higgins James D, Seeliger Katharina, Reha Sarah J, Dangel Natalie J, Bauknecht Markus, Schröpfer Susan, Franklin F Christopher H, Puchta Holger
Abstract excerpt
The human hereditary disease Fanconi anemia leads to severe symptoms, including developmental defects and breakdown of the hematopoietic system. It is caused by single mutations in the FANC genes, one of which encodes the DNA translocase FANCM (for Fanconi anemia complementation group M), which is required for the repair of DNA interstrand cross-links to ensure replication progression. We identified a homolog of...
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